| Date | Home | Score | Away | Venue |
| 20th Aug, 2015 | Dinamo Minsk | 2 - 0 | Red Bull Salzburg | OSK Brestskiy, Brest |
| 20th Aug, 2015 | Gabala | 0 - 0 | Panathinaikos | Bakcell Arena, Baku |
| 20th Aug, 2015 | Zorya Luhansk | 0 - 1 | Legia Warsaw | Valeriy Lobanovskyi Dynamo Stadium, Kiev |
| 20th Aug, 2015 | Ajax | 1 - 0 | Jablonec | Amsterdam Arena, Amsterdam |
| 20th Aug, 2015 | Molde | 2 - 0 | Standard Liege | Aker Stadion, Molde |
| 20th Aug, 2015 | PAOK | 5 - 0 | Brondby | Toumba Stadium, Thessaloniki |
| 20th Aug, 2015 | Slovan Liberec | 1 - 0 | Hajduk Split | Stadion u Nisy, Liberec |
| 20th Aug, 2015 | Krasnodar | 5 - 1 | HJK | Kuban Stadium, Krasnodar |
| 20th Aug, 2015 | Sparta Prague | 3 - 1 | Thun | Generali Arena, Prague |
| 20th Aug, 2015 | Milsami Orhei | 1 - 1 | Saint-Etienne | Zimbru Stadium, Chisinau |
| 20th Aug, 2015 | Steaua Bucuresti | 0 - 3 | Rosenborg | Arena Nationala, Bucharest |
| 20th Aug, 2015 | Young Boys | 0 - 1 | Qarabag | Stade de Suisse, Bern |
| 20th Aug, 2015 | Rabotnicki | 1 - 1 | Rubin Kazan | Philip II Arena, Skopje |
| 20th Aug, 2015 | Atromitos | 0 - 1 | Fenerbahce | Peristeri Stadium, Athens |
| 20th Aug, 2015 | Astra Giurgiu | 3 - 2 | AZ | Stadionul Marin Anastasovici, Giurgiu |
| 20th Aug, 2015 | Zilina | 3 - 2 | Athletic Bilbao | Stadion pod Dubnom, Zilina |
| 20th Aug, 2015 | Rheindorf Altach | 0 - 1 | Belenenses | Tivoli-Neu, Innsbruck |
| 20th Aug, 2015 | Bordeaux | 1 - 0 | Kairat | Nouveau Stade de Bordeaux, Bordeaux |
| 20th Aug, 2015 | Odd | 3 - 4 | Borussia Dortmund | Skagerak Arena, Skien |
| 20th Aug, 2015 | Viktoria Plzen | 3 - 0 | Vojvodina | Doosan Arena, Plzen |
| 20th Aug, 2015 | Lech Poznan | 3 - 0 | Videoton | INEA Stadion, Poznan |
| 20th Aug, 2015 | Southampton | 1 - 1 | Midtjylland | St Marys Stadium, Southampton |
| Date | Home | Score | Away | Venue |
| 27th Aug, 2015 | Videoton | 0 - 1 | Lech Poznan | Sostoi Stadion, Szekesfehervar |
| 27th Aug, 2015 | Belenenses | 0 - 0 | Rheindorf Altach | Estadio do Restelo, Lisbon |
| 27th Aug, 2015 | Athletic Bilbao | 1 - 0 | Zilina | San Mames, Bilbao |
| 27th Aug, 2015 | Rosenborg | 0 - 1 | Steaua Bucuresti | Lerkendal Stadion, Trondheim |
| 27th Aug, 2015 | Legia Warsaw | 3 - 2 | Zorya Luhansk | Polish Army Stadium, Warsaw |
| 27th Aug, 2015 | Vojvodina | 0 - 2 | Viktoria Plzen | Karadorde Stadium, Novi Sad |
| 27th Aug, 2015 | Saint-Etienne | 1 - 0 | Milsami Orhei | Stade Geoffroy-Guichard, Saint-Etienne |
| 27th Aug, 2015 | Jablonec | 0 - 0 | Ajax | Chance Arena, Jablonec nad Nisou |
| 27th Aug, 2015 | Qarabag | 3 - 0 | Young Boys | Tofiq Bahramov Republican Stadium, Baku |
| 27th Aug, 2015 | Standard Liege | 3 - 1 | Molde | Stade Maurice Dufrasne, Liege |
| 27th Aug, 2015 | Brondby | 1 - 1 | PAOK | Brondby Stadium, Brondby |
| 27th Aug, 2015 | Kairat | 2 - 1 | Bordeaux | Central Stadium, Almaty |
| 27th Aug, 2015 | Red Bull Salzburg | 2 - 0 | Dinamo Minsk | Red Bull Arena, Wals-Siezenheim |
| 27th Aug, 2015 | Rubin Kazan | 1 - 0 | Rabotnicki | Central Stadium, Kazan |
| 27th Aug, 2015 | Hajduk Split | 0 - 1 | Slovan Liberec | Stadion Poljud, Split |
| 27th Aug, 2015 | Fenerbahce | 3 - 0 | Atromitos | Sukrü Saracoglu Stadium, Istanbul |
| 27th Aug, 2015 | Panathinaikos | 2 - 2 | Gabala | Apostolos Nikolaidis Stadium, Athens |
| 27th Aug, 2015 | Midtjylland | 1 - 0 | Southampton | MCH Arena, Herning |
| 27th Aug, 2015 | AZ | 2 - 0 | Astra Giurgiu | AFAS Stadion, Alkmaar |
| 27th Aug, 2015 | Borussia Dortmund | 7 - 2 | Odd | Signal Iduna Park, Dortmund |
| 27th Aug, 2015 | HJK | 0 - 0 | Krasnodar | Sonera Stadium, Helsinki |
| 27th Aug, 2015 | Thun | 3 - 3 | Sparta Prague | Stockhorn Arena, Thun |