A glucagonoma is an unusual growth of the alpha tissues of the pancreas that multiply up to a 1000-fold overproduction of the hormonal glucagon. Alpha cell cancers are generally linked with glucagonoma problem, though similar signs are present in situations of pseudoglucagonoma problem in the lack of a glucagon-secreting growth.

This kind of growth is usually cancer that usually propagates and becomes more serious over time. Glucagonoma impacts the pancreatic islet tissues, resulting in them to generate too much glucagon.

Signs & Symptoms

Risk aspects of glucagonoma include the following:

  • Extreme thirst
  • Diarrhoea
  • Need to pee regularly (including at night)
  • Increased appetite
  • Inflammation of oral cavity
  • Rash to epidermis on face, butt, lower divisions that regularly moves
  • Crusty or scaly skin
  • Raised blisters
  • Unintentional loss of weight
  • Glucose intolerance (body has problem splitting down sugars)
  • High blood sugar levels (hyperglycemia)


In situations of dangerous glucagonoma, there are several treatments still available:

  • Two way surgery treatment: – here choices originally eliminates the glucagonoma in the pancreatic and then glucagonoma that distribute to the other aspects of the body.
  • Debulking surgery treatment: – during this process, choices will eliminate aspects of the glucagonoma to help increase the potency of eliminating the staying glucagonoma with radiation treatment. However, this kind of surgery treatment is only done if choices can eliminate more than 90% of the growth.
  • The medication octreotide or lanreotide, which may quit the growth from secreting more glucagon.
  • Interferon – this medication works by motivating the defense mechanisms to battle and battle off the growth cells.
  • Chemotherapy.
  • The medication sunitinib and everolimus which quit the growth from growing.
  • Transarterial chemoembolisation, which is a process done with an X-ray machine to prevent the veins providing tumors in the liver.
  • Radioactive atomic medication treatments such as radioactive octreotide.
  • Blood loss pills to prevent blood veins clotting coming up in the feet and the lungs.


The causes of glucagonoma are presently unidentified.

In most situations it is alleged that genetics play a powerful part. Having close relatives with several hormonal neoplasia type 1 (MEN1) is also considered as being a threat factor.

Tests & Procedures

Testing for glucagonoma may include:

  • CT scans
  • Fasting glucose level test
  • Glucose tolerance test
  • Serum glucagon test and more

Preventive Measures

  • Maintain healthy diet and weight
  • Proper diet
  • Adequate exercise
  • Avoid smoking and drinking

Treatment Cost

This rare type of cancer treatment cost depends on the stage it has been diagnosed at. The cost varies from hospital to hospital.

Side Effects

  • Infection
  • Pain
  • Anemia
  • Diarrhea
  • Headaches
  • Nausea
  • Vomiting
  • Weight loss
  • Discomfort