What is Bence-Jones Protein Test
The Bence-Jones protein urine test is conducted for the determination of Bence-Jones protein which is a globulin excreted in the urine. A Bence Jones protein is also termed as monoclonal globulin protein which is found in the urine or blood, manifesting a molecular weight of 22-24 kDa.
Why Bence-Jones Protein Test is Conducted
The purpose of evaluating the Bence-Jones protein in urine is that it can indicate for some neoplasm in the body. This is basically conducted in the medical condition of cancers such as bone marrow cancer. The detection of the protein can also be a sign of the anemia, renal failure or bone disease. The test is also recommended to detect for a rare condition called Waldenstrom’s macroglobulinemia, a type of lymphoma associated with the white blood cells.
This is one of the basic and first levels of tests that are conducted prior to moving on to more invasive techniques like biopsies. This may be followed by other examination and tests for tumor markers. Cancers of the bone marrow is significantly hard to detect in the initial stages as it is inside the bone and does not manifest any kind of specific symptoms or swelling. The only way of getting it detected is facilitating tumor markers and more invasive tests afterwards.
The undermentioned medical conditions could be potential causes of Bence Jones Proteins.
* Rheumatoid Arthritis
* Chronic Infection
Process to perform Bence-Jones Protein Test
The test is performed by taking sample of urine sample from the patient. This is ideally performed in the morning when the urine is concentrated. The urine test for Bence-Jones protein is then performed facilitating a process termed as electrophoresis. This is typically a method of concentrating urine. The substitute for this is to simply heat the urine. When the urine is heated, the Bence-Jones protein is pigmented and crystallized at a given temperature prior to getting back into the urine at the boiling point.
Preparation for Bence-Jones Protein Test
There is no particular preparation for this test nevertheless you might have to spend the entire day in the hospital continuously providing urine samples. Ideally, there should be not be any protein detected in the urine and if it is there, it would indicate the susceptibility of any of the diseases mentioned above. Some other kinds of bone disorder that can cause the protein to appear in tests can be rheumatoid arthritis. Sometimes a particular warning flashes that the high intake of acetylsalicylic acid in the form of painkillers can influence the readings.
One of the first concerns for a recently diagnosed patient is to determine whether the diagnosis is accurate. It is necessary to authenticate a diagnosis and be sure of its accuracy. Guessing for a misdiagnosis should not come on the way of getting the right treatment for a serious medical problem. Nonetheless, it is wise to attempt to cross check a diagnosis via ways like seeking second opinions, talking with specialists, getting further medical examination and tests, and researching details about the medical condition.
Misdiagnosis may and does happen and is reasonably general with error rates spanning from 1.4% in cancer biopsies to 20-40% misdiagnosis rate in emergency or ICU care.
There are several causes as to why a misdiagnosis can happen which may include human errors, errors by doctors, experts, and laboratory examinations. The patient can also be part of error in several ways.
isdiagnosis must not be taken as a feared outcome. There are several ways to ward off a misdiagnosis like seeking another opinion or a specialist consultation. Getting information about the potential substitutes or underlying diagnosis for a condition is great information to talk with your doctor.