| Year | Film & Television | Role | Notes |
| 1998 | The Jamie Foxx Show | Ola Mae | "Papa Don't Preach" (episode 14, season 2) |
| 2001 | Angel: One More Road to Cross | Guardian Angel | Direct to DVD |
| Prison Song | Mrs. Butler | Main Role | |
| Strong Medicine | Simone Fellows | "History" (episode 4, season 2) | |
| 2007 | Ghost Whisperer | Jackie Boyd | "Mean Ghost" (episode 15, season 2) |
| 2009 | I Can Do Bad All By Myself (film) | Tanya | Supporting Role |
| Untitled Nina Simone Project | Nina Simone | Main Role | |
| 30 Rock | Herself | Guest |
| Year | Category | Title | Result |
| 2009 | Best Contemporary R&B Album | Growing Pains | Won |
| Best Remixed Recording, Non-Classical | Just Fine | Nominated | |
| 2008 | Best R&B Performance by Duo/Group | "Disrespectful" (Shared with Chaka Khan) | Won |
| Best Gospel Performance | "Never Gonna Break My Faith" from the Bobby (film) soundtrack (Shared with Aretha Franklin & Harlem Boys Choir) |
Won | |
| Best R&B Female Vocal Performance | Just Fine | Nominated | |
| 2007 | Record of the Year | Be Without You | Nominated |
| Song of the Year | Be Without You | Nominated | |
| Best Pop Collaboration w/ Vocals | One (Shared with U2) | Nominated | |
| Best Traditional R&B Performance | I Found My Everything (Shared with Raphael Saadiq) | Nominated | |
| Best R&B Female Vocal Performance | Be Without You | Won | |
| Best R&B Performance by Duo/Group | Love Changes (Shared with Jamie Foxx) | Nominated | |
| Best R&B Song | Be Without You | Won | |
| Best R&B Album | The Breakthrough | Won | |
| 2004 | Best Contemporary R&B Album | Love & Life | Nominated |
| Best Female R&B Vocal Performance | Ooh! | Nominated | |
| Best Pop Collaboration w/ Vocals | Whenever I Say Your Name (Shared with Sting) | Won | |
| 2003 | Best Female R&B Vocal Performance | He Think I Don't Know | Won |
| 2002 | Best R&B Album | No More Drama | Nominated |
| Best Female R&B Vocal Performance | Family Affair | Nominated | |
| 2001 | Best R&B Performance by Duo/Group | Wyclef Jean song (Shared with Wyclef Jean) | Nominated |
| 2000 | Best R&B Album | Mary | Nominated |
| Best Female R&B Vocal Performance | All That I Can Say | Nominated | |
| Best R&B Performance by Duo/ Group | Don't Waste Your Time (Shared with Aretha Franklin) | Nominated | |
| 1999 | Best R&B Performance by Duo/Group | Lean on Me (Shared with Kirk Franklin, Bono, R. Kelly, Crystal Lewis, & The Family) | Nominated |
| 1998 | Best R&B Album | Share My World | Nominated |
| 1997 | Best Female R&B Vocal Performance | Not Gon' Cry | Nominated |
| 1996 | Best R&B Album | My Life | Nominated |
| Best Rap Performance by Duo/Group | I'll Be There For You/You're All I Need to Get By (Shared with Method Man) | Won |
